Open Access Case Study

Ulcerated Giant Lipoma over Nape of Neck – A Rare Case

Dinesh Kumar Barolia, Devendra Atal

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-4
DOI: 10.9734/JAMPS/2016/23250

Lipoma is a benign tumor composed of fat cells of adult type. It is a universal tumor as it can occur anywhere in body. Lipoma with size of more than 10 cm in one dimension or weighing a minimum of 1000 gm. called as giant lipoma [1]. Surgical excision is the treatment of choice for lipoma. We report a case of giant lipoma (4.5 kg.) causing a decubitus ulcer over the nape of the neck which is rare entity.


Open Access Case Study

Association of Butterfly Rash and Antinuclear Antibody Positivity with Inflammatory Bowel Disease

Akkamahadevi V. Nipanal, M. Parvathi, R. Madhumathi, K. V. Sanathkumar, Chandramohan .

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-6
DOI: 10.9734/JAMPS/2016/22595

A 30 year old female presented with diarrhoea and gastrointestinal bleeding, along with photosensitive rash over malar region of face. Clinically she had features of essential nutrients deficiency, extra intestinal manifestations of inflammatory bowel disease and malar rash typical of systemic lupus erythematosus (SLE). On evaluation she found to have hypothyroidism and features consistent with inflammatory bowel disease, with significantly high titres of antinuclear antibody (++++). According to 2012 SLICC SLE criteria she did not have any other features consistent with SLE. Inflammatory bowel disease was confirmed by histopathological examination showing non-caseating granuloma with no evidence of vasculitis. Patient was started on treatment with systemic corticosteroids and thyroxine supplementation. Patient responded well. No flare up of symptoms or appearance of any new symptoms during her regular follow up.

Conclusion: We conclude that, clinical and laboratory features mimicking SLE like butterfly rash, positive antinuclear antibody can occur in inflammatory bowel disease even in absence of SLE making them difficult to diagnose. But either of the patients should be regularly followed up to look for the development of the other disease. Not only graves, association of hypothyroidism following hashimotos thyroiditis is also seen with inflammatory bowel disease.


Open Access Original Research Article

Comparative Studies on the Phytochemical Properties of Five Nigerian Medicinal Plants

C. Egbuna, J. C. Ifemeje

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-12
DOI: 10.9734/JAMPS/2016/21816

Aims: This work investigated the phytochemical composition of five Nigerian medicinal plants and the significance of the phytochemicals with respect to the treatment of diseases were discussed.

Study Design: Fifteen phytochemicals were qualitatively analysed from the plants ethanolic extracts while five out of these were quantitatively determined.

Place and Duration of Study: Department of Biochemistry, Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria, between July, 2014 and August, 2014.

Methodology: Standard phytochemical analysis methods were adopted.

Results: Preliminary screening of the leaves of Psidium guajava, Azadirachta indica, Carica papaya, the rhizomes of Zingiber officinale and bulbs (cloves) of Allium sativum revealed the presence of alkaloids, tannins, flavonoids, saponins, phenols, steroids, terpenoids and carboxylic acids in all the plants ethanolic extracts. A. indica contained all the phytochemicals except coumarin, while there was the absence of anthraquinone, phlobatannin, and quinone in A. sativum. Phlobatannins was also absent in C. papaya and P. guajava extracts. There was also the absence of anthraquinone and cardiac glycosides in P. guajava and Z. officinale respectively. Resins were not detected in the plants extracts of C. papaya and Z. officinale. The quantitative analysis of the five selected phytochemicals revealed that there was significant difference in the mean values of alkaloids and flavonoids contents of the plants at P<0.05. P. guajava however, had the highest alkaloids content (1.90±0.02%) while A. sativum had the highest flavonoids content (4.20±0.02%). A. indica contained the highest phenols and tannins, (0.36±0.01%) and (2.63±0.01%) respectively. Saponins was found highest in A. sativum (2.60±0.02%).

Conclusion: The results justified the medicinal potentials of these plants in the treatment of diseases.


Open Access Original Research Article

Antibacterial Efficacy of Ageratum conyzoides on Salmonella Species Isolated from Suspected Typhoid Fever Patients in Akure Metropolis, Nigeria

O. E. Ajayi, S. I. Awala, F. N. Okogbue, A. G. Ogunleye, B. F. Olaleye

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-9
DOI: 10.9734/JAMPS/2016/23307

Aim: The study aimed at assessing the antibacterial efficacy of Ageratum conyzoides on Salmonella species isolated from suspected typhoid fever patients in Akure metropolis, Nigeria.

Study Design: The study evaluated the prospective use of Ageratum conyzoides as an alternative to commonly used drugs in the treatment of salmonellosis and gastroenteritis.

Place and Duration of Study: Five selected hospitals within Akure metropolis in Ondo State, Nigeria were used for the study which was conducted between June and September, 2015.

Methodology: Two hundred (200) blood samples collected from presumptive typhoid fever patients attending selected Hospitals in Akure metropolis were screened, and Salmonella enterica serovar Typhi and Salmonella enterica serovar Typhimurium were isolated from them. Plant used (Ageratum conyzoides Linn) was collected from Ologede Street in Oda road, Akure, Nigeria. Authentication of the plant was done at the Crop Science and Pest Department of the Federal University of Technology, Akure, Nigeria. Extract (Methanol, hexane and acetone) of the plant leaf were gotten using standard procedures. Antibacterial effects of the extract on the Salmonella isolates were thereafter evaluated followed by qualitative and quantitative phytochemical screenings on the leaf extract. The antibiogram of the isolates were also determined using Antibiotics sensitivity disc.

Results: The highest zone of inhibition was observed with the methanol extract at a concentration of 100 mg/ml for Salmonella Typhi and the lowest with the acetone extract at 25 mg/ml. The highest zone of inhibition was however observed for the hexane extract at a concentration 100 mg/ml for Salmonella Typhimurium and the least with methanol extract at 12.5 mg/ml. Phytochemical analysis revealed the presence of various secondary metabolites in the plant.

Conclusion: Ageratum conyzoides leaves extracts if further investigated for its antibacterial properties, possess the potential of creating a roadmap for drug formulation especially against salmonellosis.


Open Access Original Research Article

Knowledge, Attitude and Practice about Household Poisoning in Saudi Arabia

Samia S. Barghash, Azza El. Tlt, Huda A. Al-Jemily

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-12
DOI: 10.9734/JAMPS/2016/23115

Background: Food poisoning, household poisoning, and cosmetic poisoning are becoming a very important health problem both worldwide and locally at the level of the Kingdom of Saudi Arabia (KSA). The aims of this study was to assess knowledge, attitude and practice about the storage and utilization patterns of household poisoning in Saudi Arabia and assess the adverse and toxic effects that respondents have experienced upon utilizing these products. Also, we attempted to identify risks imposed on the community due to improper storage and exposure to household belongings.

Methods: Cross-sectional survey was designed and distributed electronically in Saudi Arabia. The questionnaire was conducted on 503 Saudi Arabian subjects, aged from 18-70 years old in March, 2015. It included questions regarding demographic characteristics, storage, utilization habits, and adverse effects experienced by respondents upon handling the household products.

Results: It was found that the main reasons of poisoning were the lack of knowledge, the easy access to household product, and the unsafe storage of these products. The majority of accidental events occurred with food products, cleaning agents, cosmetics products and pesticides, respectively. Respondents stored household products in different places in their homes, but most of these storage places were suboptimal and were within reach of children. The majority of cases experienced adverse and toxic effects of cleaning products and pesticide and petroleum distillates were children younger than 6 years of age.  While the majority of cases experienced adverse and toxic effects of food poisoning and cosmetics were between 12-18 years and more than 18 respectively. Most of respondents reported mixing of cleaning products. Most of respondents (60.52%) were careless regarding taking safety precautions while dealing with pesticides and petroleum distillates. About 50.83% of respondents ignoring the content of any household product. 

Conclusions: Correct utilization and safer storage of household products is encouraged. Several preventive strategies should be implemented in order to decrease the incidence of accidental harmful exposure that is due to cleaning agents.  Improving the knowledge and educating the population regarding this type of poisoning will limit the cases of household poisoning among our country.