Open Access Case Study

Diagnostic Difficulty of Breast Lump- Revealed a Rare Entity

Pandiaraja .

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-3
DOI: 10.9734/JAMPS/2015/20643

Lipoma is a benign soft tissue tumor of adipose tissue. Most of the time lipoma is diagnosed based on clinical features. Histopathological confirmation needed in certain cases. There are many subtypes of lipoma. One of the rare variant of lipoma is chondrolipoma. This is a case report of 58 years old female presented with lump in the right breast which has a diagnostic difficulty. Later it was diagnosed as chondrolipoma of breast. This case is reported due to its rarity in breast.


Open Access Original Research Article

Acute and Sub-acute Toxicity of HRT 123 Polyherbal Formula

Kakjing D. Falang, Mary O. Uguru, Jurbe G. Gotep

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-8
DOI: 10.9734/JAMPS/2015/16877

Plant based drugs (single or multi-component formulations) have been used in managing many health conditions worldwide. One such formulation is the herbal formula HRT 123 which is being used in managing conditions involving immunosuppression, HIV/AIDs and other infectious diseases of viral origin. This study screened for phytochemical constituents and evaluates acute and sub acute toxicity profile of aqueous HRT 123 extract. We evaluated acute toxicity of HRT 12 aqueous extract using the modified Arithmetic method of Karbar and sub-acute toxicity using the 14-day repeated dose oral toxicity testing procedure. For sub acute toxicity, thirty albino rats divided into five groups of six rats each received 0, 250, 500, 750, and 1000 mg/kg of extract respectively by oral route for 14 days. Animals were sacrificed and blood analyzed for haematological parameters, serum biomarkers and electrolytes while visceral organs (lungs, heart, liver, kidneys & spleen) were harvested for histopathological investigations. Phytochemical screening shows presence of alkaloids, saponins, tannins, flavonoids and carbohydrates. Acute toxicity shows oral LD50 to be more than 6000 mg/kg. Following sub acute administration, indices of liver (AST, ALT, total protein & albumin) and renal (sodium, potassium, chloride & creatinine) function and; haematological parameters were not significantly different in treated groups relative to controls. Liver weight displayed a dose dependent increase while the kidneys showed relative but non-significant decrease. These results are suggestive of the relative safety of HRT 123 but caution needs to be exercised with used of high doses and in the face of concomitant liver or kidney abnormality.


Open Access Original Research Article

Assessment of Thrombolytic Activity of Selected Species from Lamiaceae Family Growing Naturally in Kurdistan Region\Iraq Using In-vitro Model

Lana Yousif Mutalib

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-5
DOI: 10.9734/JAMPS/2015/20550

Aims: The present study was aimed to assess most commonly used medicinal plant belong to Lamiaceae family for their thrombolytic activity.

Place and Duration of the Study: Pharmacy College\ Hawler Medical University, June, 2015.

Methodology: Dried leaf part ethanolic extracts of selected species have been evaluated for their thrombolytic activity using fresh human blood specimen at concentrations of 200, 400, 600, 800 and 1000 µg\ml, streptokinase drug and distilled water were incorporated in the study as control positive and negative, respectively.

Results: Showed significant thrombolytic activity of leaf extracts at all tested concentrations in comparison with control negative distilled water (P < 0.01), highest clot lysis activity were recorded for Salvia officinalis leaf extract (68.43±1.457%) and minimum activity were exhibited by Rosmarinus officinalis leaf extract (49.27±3.256%). Salvia officinalis and Thymus vulgaris expressed significant thrombolytic activity in comparison with control positive streptokinase            (P < 0.05) at highest tested dose concentration (1000 µg\ml).

Conclusion: Selected species from Lamiaceae plant family can open a venue for production of thrombolytic drugs derived from natural source with greatest activity and lowest adverse effects.

Open Access Original Research Article

QSAR Study of Nickel-Schiff Base Complexes as Anti-bacterial Agents against Staphylococcus aureus

J. P. Ameji, A. Uzairu, S. O. Idris

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-18
DOI: 10.9734/JAMPS/2015/20379

Aim: To develop good and rational Quantitative Structure Activity Relationship (QSAR) mathematical models that can predict to a significant accuracy the anti-Staphylococcus aureus Minimum inhibitory concentration (MIC) of Ni-Schiff base complexes.

Place and Duration of Study: Department of Chemistry (Physical Chemistry unit), Ahmadu Bello University, Zaria, Nigeria, between January and June 2015.

Methodology: A set of 36 nickel-Schiff base complexes with their antibacterial activities in terms of minimum inhibitory concentration (MIC)  against the gram-positive bacteria, Staphylococcus aureus were selected for 0D, 1D, 2D and 3D quantitative structure activity relationship (QSAR) analysis by means of Density Functional Theory (DFT) using the Becke’s three-parameter hybrid functional (B3LYP) and 6-31G* basis set. The computed descriptors were correlated with their experimental MIC. Genetic function approximation (GFA) method and Multi-linear regression analysis (MLR) was used to derive the most statistically significant QSAR model.

Results: Among the obtained QSAR models, the most statistically significant one was a tri- parametric linear equation with the squared correlation coefficient R2 value of 0.9399, adjusted squared correlation coefficient R 2adj value of 0.9313 and Leave one out (LOO) cross validation coefficient (Q2) value of 0.9074. An external set was used for confirming the predictive power of the model, its R2pred = 0.9725.

Conclusion: The QSAR results reveal that molecular size and polarity predominantly influence the anti-Staphylococcus aureus activity of the complexes. The wealth of information in this study will provide an insight to designing novel bioactive nickel-schiff base complexes that will curb the emerging trend of multi-drug resistant strain of Staphylococcus aureus.


Open Access Review Article

A Review on Barleria prionitis: Its Pharmacognosy, Phytochemicals and Traditional Use

Sattya Narayan Talukdar, Md. Bokhtiar Rahman, Sudip Paul

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-13
DOI: 10.9734/JAMPS/2015/20551

Barleria prionitis, belonging to Acanthaceae family, is a small spiny shrub, normally familiar as “porcupine flower” with a number of vernacular names. It is an indigenous plant of South Asia and certain regions of Africa. The therapeutical use of its flower, root, stem, leaf and in certain cases entire plant against numerous disorders including fever, cough, jaundice, severe pain are recognized by ayurvedic and other traditional systems. As a significant source of secondary metabolites including saponin, tannin, flavonoid, alkaloid, glycoside, phenolic compounds recent pharmacognostical screening renders its effectual functions as potent antioxidant, anti-microbial, anti-inflammatory, hepatoprotective, gastro-protective agent etc. Although having a potential remedial significance, it is still underutilized. This review can be considered as a bird’s eye view highlighting the current progress of Barleria prionitis in pharmacological and pharmacognostical field with its prominent folk uses.