Open Access Original Research Article

Anti-myocardial Infarctus, Efficient Antipoison and Anti-prostate Mighty Spicy Miscellany

A. B. Kunyima, P. D. M. D. Kunyima, J. C. Kuburhanwa, M. B. Kunyima

Journal of Advances in Medical and Pharmaceutical Sciences, Page 1-14
DOI: 10.9734/jamps/2022/v24i8569

Background: Cardiovascular diseases, cancers and diabetes that are the main cause of mortality in the world have as principal origine the lack of food (life) hygiene and environmental pollution at which it should be added the synthesis chemical products and the poisons playing a prominent and active role in this human drama. In this paper it is shown that with spicy blend rationally performed on the basis of their natural properties, prostate and myocardial infarction can be healed. Also this mixture can treat some poisons when detected before.

Aim and Objective: The laboratory of physical organic chemistry, food and physical cardiochemistry, Lacopa-CCP in acronym, has just developed a powerful blend of spices based on Turmeric called PdeluxeKK (Paulin Deluxe KUNYIMA KUNYIMA), conceived at the beginning to treat a myocardial infarction caused by poisoning clinically established and after become unexpectedly efficient in the treatment of a prostate and other poisons.

Methodology: This mixture contains in order turmeric in large quantity, ginger, black pepper, garlic and red onion, original pure honey and the variant of PdeluxeKK incorporates at the end before the honey the red beetroot to make this mixture more reliable against cyanide poisons through its betacyanin and to prevent eventual anemic problems during the treatment. The order of the mixture is of great importance because it has been observed that its effectiveness changes not only with the proportions of the components involved but also according to the order of addition of the components which constitute this mixture. The mixture pastry should be kept between - 5°C and 0°C.

Results: Prostate and myocardial infarction clinically established have been satisfactorily treated by PdeluxeKK. Also many poisons detected in human body are successfully treated by PdeluxeKK.

Conclusion: This mighty spicy miscellany successfully treats prostate, myocardial infarction and certain poisons.

Open Access Original Research Article

An Appraisal of the Quality of Outpatient Healthcare Services and Patients’ Satisfaction at a Nigerian Mission Health Facility

Collins N. Ugwu, Ogbonnaya Ogbu, Ngozi I. Ugwu, Nneka M. Chika-Igwenyi, Richard C. Ikeagwulonu, Onyedikachi E. Chukwu, Amadi U. Kalu, Olaronke F. Afolabi, Tobechukwu C. Iyidobi, Chigozie J. Uneke

Journal of Advances in Medical and Pharmaceutical Sciences, Page 15-27
DOI: 10.9734/jamps/2022/v24i8570

The cardinal goal of the hospital is to provide quality healthcare services to the patients, which is measured by patient’s satisfaction. This study aimed to determine patients’ knowledge and satisfaction about the factors that contribute to quality of outpatients’ healthcare services, to determine whether socio-demographic factors have any effect on patient satisfaction and to determine the effect of educational intervention on their knowledge and satisfaction. A quasi-experimental study (in which before-after technique) was carried over six months period. Systematic sampling technique was used to recruit adult patients exiting the out-patient department of the hospital. A semi-structured, interviewer administered modified SERVQUAL questionnaire was used to assess satisfaction and knowledge, followed by educational intervention and subsequently post intervention assessment after two months. The data generated were analysed using SPSS software version, 26. Three hundred and fifty adult patients participated in the pre-intervention stage while 165 patients were interviewed post-intervention. The proportion of the participants who had good knowledge pre-intervention, was high (91.7%) while 88.3% were satisfied with the quality of healthcare services. The empathy domain had the highest mean score of 4.02 while the responsiveness domain had lowest mean score of 3.29. Post-intervention, the knowledge level improved from 91.7% to 95.2% and satisfaction improved from 88.3% to 96.2% with mean score of 4.14. Gender did not have any influence on the level of knowledge and satisfaction across the various domains. However, there was increased satisfaction among the older patients (≥50 years) which was statistically significant [Tangible domain (X2 = 22.621, P = 0.000)]. Educational intervention was effective in improving level of knowledge about the factors that influence quality of care and level of satisfaction with the quality of care received at the hospital. The hospital management needs to prioritize interventions to improve the responsiveness of the services provided in the hospital to improve the quality of service and enhance patients’ satisfaction.

Open Access Original Research Article

Screening for Iron Deficiency in Early Childhood Using Serum Ferritin

Animesh Mahajan, Ravinder K. Gupta, Rachna Sabharwal, Pallavi Mahajan

Journal of Advances in Medical and Pharmaceutical Sciences, Page 28-33
DOI: 10.9734/jamps/2022/v24i8571

Introduction: The iron deficiency is an important public health problem widely prevalent in the early childhood period. Iron is very important for various body processes like monoamine metabolism, synthesis of myelin, and metabolic function of the brain. It has many detrimental effects on the cognition, emotional, social, and motor development.‍ Serum ferritin is an easily available, non invasive, inexpensive with high specificity for iron deficiency.

Aim: The present study was conducted with the aim to estimate the levels of hemoglobin and serum ferritin in young children in the age group of 1-5 years irrespective of their sex. 

Materials and Methods: Laboratory data of serum ferritin and hemoglobin levels were prospectively collected of apparently healthy children, 1 to 5 years of age coming to Pediatrics OPD of Acharya Shri Chander College of Medical Sciences, Jammu. The ferritin levels were estimated in roche chemiluminescent immunoassay. The haemoglobin levels were estimated. Children with serum ferritin level < 12 µg/L was considered as deficiency. The statistical analysis was conducted using SPSS version 20.

Results: A total of 100 children, 1 to 5 years of age were enrolled in the study. The mean hemoglobin level in children is 12.2gm%. The mean serum ferritin level in children is 29.2µg/L. In our study, it was observed that the mean Hb levels are higher in the reference age group, than decreases in the 2-3 year age group and then again increases in the 3-5 years age group. It was further observed that the serum ferritin levels were higher in the reference age group and then decreases in the 2-3 year age group. The serum ferritin levels further rises in the 3-4 years, 4-5 years age group.

Conclusion: In our study, it was observed that serum ferritin is a more reliable test than hemoglobin for screening iron deficiency in early childhood. The most favorable age group for screening for iron deficiency appears to be 2 to 3 years of age in which maximum number of children with iron deficiency was observed, but other associated conditions should also be kept in mind.

Open Access Original Research Article

Anticonvulsant Activity of Methanol Extract of Harungana madagascariensis Leaf on Mice Model of Isoniazid-induced Siezure

Ugwu Obiora Celestine, Ali Ibeabuchi Jude, Felix Keneolisa Asogwa, Okonkwo Raymond Maduabuchi, Nwafor Samuel Nnamdi

Journal of Advances in Medical and Pharmaceutical Sciences, Page 34-41
DOI: 10.9734/jamps/2022/v24i8572

Background: Epilepsy is a neurological illness that affects people of all ages and is characterized by excessive electric activity in the brain. This causes social embarrassment coupled with side effect of orthodox medication; hence, the needs to search for plant with antiepileptic agent.

Aims: This study aimed at investigating the anticonvulsive effects of Methanol extract of  Harungana madagascriensis leaves on the isoniazid-induced (300 mg/kg, i.p) seizure in adult mice.

Study Design: This is an original research carried out in the Department of Pharmacology, Faculty of pharmaceutical Sciences, Enugu State University of Science and Technology (ESUT), Agbani, Enugu State, Nigeria, between Jan and June, 2021.

Methodology: The pulverized leaf of Harungana. madagascariensis was extracted using cold maceration and the phytochemical screening was carried out by the method of Treas and Evans The acute toxicity study was evaluated by the method of Lorke’s and Anticonvulsant study was carried by the method of Webster and Velluci. Data generated was statistically analyzed using one way ANOVA.

Results: Preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, phenols, glycosides, saponins, terpenoids and steroids. Flavonoids, Phenols, and terpenoids appeared in abundant concentration (4264.00 ±360.2,14065.00 ±538.4, 5484.00±30.4). Acute toxicity tests showed no toxicity and mortality at doses up to 5000 mgkg-1. Anticonvulsant study revealed that the extract significantly (p =.05) delayed the onset of clonic seizure in a dose dependent manner and abridge the duration of siezure on the group treated with 100, 500 and 1000 mg/kg b.w of extract compared with normal control when induced with isoniazid (300 mg/kg, i.p.).

Conclusion: The results suggest that methanol extract of Harungana. madagascariensis leaves may have anticonvulsant activity, coupled with the presence of active secondary metabolites such as saponins, steriods and flavoniods which has a potentials for the management of epilepsy.

Open Access Original Research Article

Assessment of Effectiveness of the Recognition of Stroke in the Emergency Room Scale in Emergency Department of Suez Canal University Hospital, Egypt

Sarah Khaled Abdelaati, Nashwa M. Abdelgeleel, Ahmed El Sayed Abou Zeid, Rasha M. Ahmed

Journal of Advances in Medical and Pharmaceutical Sciences, Page 42-53
DOI: 10.9734/jamps/2022/v24i8573

Background: The Recognition of Stroke in The Emergency Room (ROSIER( scale has been designed to provide physicians in the emergency department with a framework which can be used to assess patients with suspected stroke and to facilitate early identification of acute stroke & appropriate referral.

Aims: To assess the sensitivity and specificity of the ROSIER score in order to improve outcome of stoke patients.

Methodology: The current study was designed as a prospective cross sectional study that included Patients over 18 years of age with suspected stroke presenting at emergency department in Suez Canal university hospital.

Results: Patients with stroke formed about 65.2% of the patients with suspected stroke in the ER. Patients with stroke/ TIA were found to have significantly higher age compared to other patients (63.58 ±12.55 vs 39.18±11.12) (p<0.001). The most frequent comorbid diseases among patients were hypertension and diabetes mellitus. For ROSIER accuracy, a value of 1.00 or more was found to be the best cut-off point for prediction of stoke among patients attending with suspected stroke, with sensitivity = 98.3% and specificity = 87.5 % and accuracy= 94.5%.

Conclusion: The ROSIER scale is simple, rapid, effective and sensitive screening tool in early detection of patients presenting with stroke and differentiating stroke from stroke mimics in the emergency room.