Journal of Advances in Medical and Pharmaceutical Sciences <p style="text-align: justify;"><strong>Journal of Advances in Medical and Pharmaceutical Sciences (ISSN:&nbsp;2394-1111)</strong> aims to publish high quality papers (<a href="/index.php/JAMPS/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;Medical and Pharmaceutical Sciences. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.&nbsp;</p> SCIENCEDOMAIN international en-US Journal of Advances in Medical and Pharmaceutical Sciences 2394-1111 Physical Abuse in Its Extreme form Seen in a 12-Year-Old Female Adolescent <p><strong>Background: </strong>Child abuse occurs very frequently in Nigeria with approximately 6 out of every 10 children experiencing some form of violence. An estimate of 1 in every 4 girls and 1 in every 10 boys have undergone some form of sexual violence. Unfortunately this human violation often elicits little or no attention particularly where the abuser happens to be a close relative.</p> <p><strong>Case</strong><strong>:</strong> A 12 year old female adolescent was admitted into the children emergency room of a Nigerian tertiary institution with high grade fever and bilateral painful leg swelling following physical abuse by her biological father. This was buttressed with the findings made on examination.</p> <p>Parenteral anti-inflammatory and antibiotics were administered with surgical drainage of the lesions. The mental state of the Patient was evaluated by the Psychological Medicine Experts /Psychiatrist and also had counselling sessions during the course of treatment and shortly before discharge. Patient responded well to treatment and was discharged to the care of the women and children welfare unit of the State Ministry of Women Affairs.</p> <p><strong>Conclusion</strong><strong>:</strong> This case report underscores the need for continuous awareness creation on the inherent dangers of child abuse for both the general public and the Health practitioners.</p> Ajaegbu Obinna Okike Clifford Onuorah Muoneke Uzoamaka Vivian ##submission.copyrightStatement## 2020-12-31 2020-12-31 15 19 10.9734/jamps/2020/v22i1130201 Ameliorative Effect of Nutmeg (Myristica fragrans) Supplement against Acetaminophen - Induced Hepato-Renal Toxicity in Wistar Rats <p><strong>Background:</strong> Recently, many drugs have been developed and used for the treatment of hepatic and renal diseases. Nutmeg apart from being utilized as kitchen spices in Nigeria has also been used for healing and medicinal purposes.</p> <p><strong>Aims:</strong> In the present study, nutmeg supplement was evaluated against Acetaminophen (APAP) induced hepato- renal-toxicity.</p> <p><strong>Study Design:</strong> Twenty (20) adult wistar rats weighing185-220 were obtained from animal house of the department of&nbsp; Pharmacology University of Port Harcourt were divided into four groups having 5 rats each (n=5).</p> <p><strong>Methodology: </strong>The animals were divided into four groups of 5 rats each: Group A (normal control) were administered distilled water, group B (negative control) received a single dose of acetaminophen (1000 mg/kg) for two days. Group C received 500 mg/kg body weight of nutmeg supplement one hour before receiving 1000 mg/kg acetaminophen, while group D received acetaminophen (1000 mg/kg) only on day 1 and 2 and the drug extracts on day 3-7. All dosage was dissolved in distilled water orally. The experiment lasted for seven days. Twenty four hours after drugs administrations the animals in each group were anaesthetized. Blood samples were collected and animals sacrificed, liver and kidney tissues removed for various histopathological, biochemistry, antioxidant and haematological examinations using standard procedures. Statistical analysis was done using ANOVA and Tukey poc-hoc Test.</p> <p><strong>Results:</strong> Administration of nutmeg supplement orally effectively restrained APAP-induced alterations in the activities of hepatic (48.60-38.00) and renal markers and Antioxidant enzymes in liver (0.43-0.53). The hepatic and renal architecture of APAP administered rats showed distorted liver and kidney tissues, hepatic vacuolations, destroyed glomerular and renal tubules. Nutmeg+APAP as well as APAP+ Nutmeg administrations were able to ameliorate the effects of APAP administration.</p> <p><strong>Conclusion: </strong>The result indicated that APAP overdosed is hepato-renal- toxic and Nutmeg supplement possessed hepato-prote-curative properties as well as renal-prote-curative properties against APAP-induced damage in rats.</p> Chukwunyere Ogechi Abaekwume Hope Delesi Kagbo ##submission.copyrightStatement## 2020-12-31 2020-12-31 1 14 10.9734/jamps/2020/v22i1130200