Journal of Advances in Medical and Pharmaceutical Sciences

Posterior Uveitis with Serous Retinal Detachment as a Severe Extra-Articular Manifestation of Psoriatic Arthritis: A Case Report

Soukaina Mounsif — 2026-05-13

Background: Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease that may be associated with extra-articular manifestations, including uveitis. Ocular involvement is uncommon in PsA and usually limited to anterior uveitis. Posterior uveitis complicated by serous retinal detachment is rare and potentially sight-threatening.

Case Presentation: We report the case of a 52-year-old man with no significant past medical history, followed for psoriatic arthritis fulfilling the CASPAR criteria. The disease was initially well controlled with methotrexate. After several months, he developed unilateral visual impairment. Ophthalmologic examination revealed anterior uveitis (Tyndall 3+) associated with posterior uveitis complicated by serous retinal detachment. Extensive biological and imaging investigations excluded infectious causes. The patient was treated with intravitreal triamcinolone acetonide followed by infliximab (weeks 0, 2, and 6, then every 8 weeks), leading to marked improvement of both ocular and articular manifestations. Visual acuity improved from 2/10 at presentation to 7/10 at follow-up.

Conclusion: This case highlights that psoriatic arthritis–associated uveitis may involve the posterior segment and lead to severe retinal complications. After exclusion of infectious etiologies, anti–TNF-α therapy represents an effective and steroid-sparing treatment option in severe PsA-associated uveitis.

Recent Advances and Mechanistic Insights into Hydrotropic Solubilization: From Conventional Agents to Novel Combination Strategies

G. W. Ugodi — 2026-04-18

The poor aqueous solubility of emerging drug candidates remains a formidable challenge in pharmaceutical development, directly limiting oral bioavailability and therapeutic efficacy. Hydrotropic solubilization has gained significant attention as a versatile, cost-effective, and environmentally friendly technique to enhance the solubility of hydrophobic drugs without the need for organic solvents. This review provides a comprehensive overview of recent advances in the fundamental mechanisms underlying hydrotropy, including molecular self-aggregation, complexation, and the role of the Minimum Hydrotropic Concentration in initiating the solubilization process. The discussion categorizes hydrotropic agents into synthetic, natural, and novel classes, highlighting a strategic shift toward biocompatible and green alternatives. Findings from literature revealed recent advances in formulation strategies, such as the development of hydrotropic solid dispersions and mixed hydrotropy: a synergistic approach that achieves multifold solubility enhancement while minimizing individual agent concentrations and potential toxicity. By integrating advanced characterization techniques; including spectroscopic, microscopic, and thermodynamic studies with a critical analysis of regulatory and safety considerations for the commercialization of hydrotropic systems. These insights provide a structural framework for overcoming the solubility barrier and optimizing the delivery of next-generation therapeutic agents using hydrotropes.

Antioxidant and Antibacterial Activities of Aqueous and Hydroethanolic Extracts from the Pericarp of Garcinia mangostana L.

Jaures Arnaud Noumedem Kenfack — 2026-05-09

Background: Oxidative stress and antibiotic-resistant bacterial infections pose major global health challenges, increasing interest in plant-based alternatives. Garcinia mangostana is traditionally used for its bioactive compounds with potential antioxidant and antibacterial properties.

Aim: To carry out a phytochemical screening and to evaluate the antioxidant and antibacterial activity of aqueous and hydroethanol extracts from the pericarp of the fruit of Garcinia mangostana (Clusiaceae).

Methodology: Hydroethanolic Extracts from the Pericarp of Garcinia mangostana L were prepared and phytochemical screening was carried out using colorimetric tests for qualitative analysis and spectrometric assays for quantitative analysis. Antioxidant activity was assessed by FRAP and DPPH methods. Antibacterial activity was determined using the Broth Microdilution technique on 4 bacterial strains including Enterobacter cloacae, S. aureus, Escherichia coli, Pseudomonas aeruginosa. The bacteria sought came from samples analyzed at the Microbiology Laboratory of the University Clinics of the Mountains, purified on nutrient agar.

Results: Extraction yields varied from 1% to 2.76%. The highest yield was obtained by hydroethanol maceration (2.76%), while the lowest was obtained by aqueous maceration (1%). Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, phenols, tannins and anthocyanins, with a higher concentration of total phenols in each extract. In addition, the hydroethanol extract showed the best anti-free radical activity particularly when measured using the DPPH method, where the IC50 of 15.71 µg/mL was lower than that obtained with butylhydroxy toluene extract (IC50 of 17.91 µg/mL). Although the opposite result were obtained using the FRAP method (IC50 of 18.97 and 15.82 µg/mL respectively), the IC50 value remained below 20 µg/mL indicating strong antioxidant activity of hydroethanol extract. In parallel, the same hydroethanol extract showed strong inhibition of Enterobacter cloacae (0.16µg/ml), S. aureus (0.32µg/ml) and Escherichia coli (0.64µg/ml), while Pseudomonas aeruginosa was inhibited with a lower concentration 0.24µg/ml of aqueous decoction than the other extracts.

Conclusion: Hydroethanolic extracts of Garcinia mangostana pericarp possess antioxidant and antibacterial properties, justifying their use in traditional medicine.