Journal of Advances in Medical and Pharmaceutical Sciences 2020-08-14T17:28:05+00:00 Journal of Advances in Medical and Pharmaceutical Sciences Open Journal Systems <p style="text-align: justify;"><strong>Journal of Advances in Medical and Pharmaceutical Sciences (ISSN:&nbsp;2394-1111)</strong> aims to publish high quality papers (<a href="/index.php/JAMPS/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;Medical and Pharmaceutical Sciences. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.&nbsp;</p> Estimating Glomerular Filtration Rate Using Full Age Spectrum Equation to Assess Kidney Function in Hypertensive Patients: A Cross-sectional Study 2020-08-14T17:28:05+00:00 Balkar Chand Lovleen Bhatia Kanchan Vohra <p><strong>Background:</strong> Estimated glomerular filtration rate (eGFR) is accepted as the best indicator of kidney function and commonly assessed from serum creatinine (Cr) and cystatin C (Cys-C) based equations. The present cross-sectional, observational study aimed to assess eGFR using a new and validated Full Age Spectrum (FAS) equation and compared with eGFR assessed using old and established equations in hypertensive patients.</p> <p><strong>Materials and Methods:</strong> Overall, 60 subjects were recruited for the study, including 30 hypertensive patients and 30 age and sex matched healthy subjects. Serum creatinine and cystatin C were measured using commercial biochemical kits. These levels were used to derive and compare eGFR using our different equations, namely, Cockcroft and Gault (CG), Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease-epidemiology collaboration (CKD-EPI), and FAS equation. Student t-test was used for comparison between two groups and One-way ANOVA test was used to find multiple comparison with-in the hypertensive and control group. Pearson’s Univariate correlation followed by multiple linear regression analysis was applied to find independent predictors of eGFR. All data were analyzed using Sigma-Stat.</p> <p><strong>Results: </strong>There was significant difference found in the eGFR levels using different equations in hypertensive subjects as compared to healthy subjects (<em>P</em>&lt;0.01). With–in hypertensive subjects and with-in heathy subjects, a significant difference was also reported (both <em>P</em>&lt;0.01). For FAS-based GFR, age was found as independent predictor of eGFR by all FAS equations. eGFR estimated using Cr based equations resulted in significant difference in categorizing number of subjects into CKD v/s non-CKD depending on their eGFR levels. But there was no difference found for the above in serum cystatin C based equations (<em>P</em>=0.26).</p> <p><strong>Conclusion:</strong> Present data showed that eGFR derived using all set of equations resulted in variable eGFR levels. But, use of Cr based equations instead of Cys-C or combine Cr-Cys based equations resulted in wide variation <em>i.e.</em> change in GFR due to change in marker.</p> 2020-08-10T00:00:00+00:00 ##submission.copyrightStatement## Analgesic Effects of Vigna unguiculata subsepecies dekindtiana in Mice 2020-08-14T10:52:51+00:00 Adekunle T. Adegbuyi Moses A. Akanmu G. Olayiwola Abayomi O. Sijuade <p>In the present study, we investigated the antinociceptive effects of the plant <em>Vigna unguiculata</em> spp <em>dekindtian</em>a using chemical and thermal tests in mice. The peripheral and the central analgesic activities of the methanol extract and its fractions were investigated in-vivo in albino mice using acetic acid induced-writhing test and hot plate models respectively. The result of the central analgesic effect showed that the methanol extract (VUME) at 400 mg/kg produced a significant (p&lt;0.05) delay in reaction time in mice on hot plate compared to the control. Various fractions of the extract showed more potency compared to the crude extract. In acetic writhing model, the extract and the fractions demonstrated dose dependent reduction in writhing reaction induced by acetic acid in mice. The reduction was significant when compared to control which was suggestive of the analgesic effect of the plant. It was also seen that the extract and fractions showed an improved analgesic effect compared to diclofenac used as positive control in this model. Yohimbine (alpha adrenergic receptor antagonist) and cyproheptadine (serotonergic receptor antagonist) reversed the antinociceptic effect of the fractions in the hot plate model demonstrating the possibility of adrenergic and serotonergic involvement in eliciting the analgesic effect. Naloxone on the other hand, caused a reversal only in the butanol fraction meaning that this fraction may contain active principles that may mediate their analgesic effect through the opioid mechanism. In the writhing test, yohimbine abolished the analgesic effect of both hexane and butanol fractions. This may therefore, suggest that the analgesic effect of these fractions may be mediated through adrenergic pathway. In conclusion, the plant <em>V</em>. <em>unguiculata</em> subspecies <em>dekindtiana</em> possesses active principles with potential analgesic activity, establishing the folkloric use of the plant in managing pain.</p> 2020-08-14T00:00:00+00:00 ##submission.copyrightStatement##