Journal of Advances in Medical and Pharmaceutical Sciences 2021-04-22T21:14:22+00:00 Journal of Advances in Medical and Pharmaceutical Sciences Open Journal Systems <p style="text-align: justify;"><strong>Journal of Advances in Medical and Pharmaceutical Sciences (ISSN:&nbsp;2394-1111)</strong> aims to publish high quality papers (<a href="/index.php/JAMPS/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;Medical and Pharmaceutical Sciences. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.&nbsp;</p> Oral Quercetin in Adult Patients as a Potential Nutraceutical against Coronavirus Disease 2019 (COVID-19) 2021-04-22T21:14:22+00:00 Juan Fernando Ibarra Aguilar Gabriela Ariane Sanabria Báez Fernando Galeano <p><strong>Aim: </strong>To establishing the use of oral Quercetin as a potential nutraceutical against Coronavirus Disease 2019.</p> <p><strong>Methods:</strong> A descriptive, prospective longitudinal study was carried out on 52 patients treated at the ECOMED-LAMB Clinic, in the period from the onset of Covid-19 in our country, March 3, 2020 to January 2021.</p> <p><strong>Results:</strong> Were studied 52 patients COVID-19 positive, 20 (38.4%) were in preventive treatment and 32 patients (61.5%) was administered biological therapy once the diagnosis, no difference was found between female or male sex and the predominant age was those over 60 years. Twenty-four patients (70.6%) have presented at least one comorbidity.</p> <p>The association of hospitalization with preventive treatment was not significant (p=0.166), we observed difference in the evolution of the patients (p= 0.084).</p> <p><strong>Conclusions:</strong> Quercetin could prevent and decrease the duration of SARSCoV-2 infections, it is plausible to propose the prophylactic use of this flavonoid in order to achieve clinical benefits.</p> 2021-04-08T00:00:00+00:00 ##submission.copyrightStatement## Phytochemical Screening, Antioxidant Activity and Inhibitory Potential of Five Kenyan Medicinal Plants 2021-04-22T21:14:22+00:00 Mukhwana Dennis Wafula Ayieko Cyrus Mweresa Collins Ingonga Johnstone Matoke-Muhia Damaris <p>The present study was conducted to evaluate preliminary phytochemical analysis and <em>in vitro </em>antioxidant activities of five plants (<em>Olea europaea, Kigelia africana, Terminalia mollis, Croton macrostachyus and Bridella micrantha </em>extracts). The plants were collected from Baringo County in Kenya, dried, pulverized into fine powders and extracted using methanol. Phytochemical analysis showed the presence of alkaloids, aminoacids and proteins, flavonoids, saponins, steroids, tannins and triterpenoids. The root extracts were further investigated for their potential antioxidant activity by using radical scavenging DPPH (2, 2-Diphenyl-2-picryl-hydrazyl) technique. Methanol extract of roots from the plants showed significant differences in DPPH radical scavenging activities. The results were concluded that extracts have a more secondary metabolites and potential source of antioxidants, which is warranty to evaluate further <em>in vivo </em>pharmacological studies.</p> 2021-04-12T00:00:00+00:00 ##submission.copyrightStatement## Medicinal Potentials of Ocimum gratissimum Linn Leaf Extract against Lead Acetate Disruptions in Rat Hippocampus and Electrolyte Concentration 2021-04-22T21:14:21+00:00 Ubi Essien Isaac <p>The present study determined the effect of <em>Ocimum gratissimun </em>Linn. leaves aqueous extract on lead-acetate alterations in the hippocampus and serum biochemical concentration of sodium (Na<sup>+)</sup> and potassium (K<sup>+) </sup>ions in animal models. Twenty male and female albino rats weighing around 155 g were randomly distributed to four groups, (n=5 each). Group A served as control, B received 500 mg/kg body weight of <em>O. gratissimum</em> leaf extract, C was administered 150 mg/kg of lead acetate, and group D was given both lead acetate and the named leaf extract at doses of 150 mg/kg and 500 mg/kg respectively. Treatments were given once daily via gavage and lasted 15 days while the animals had access to feed and water <em>ad libitum</em>. The rats were euthanized on the 16<sup>th</sup> day by cervical dislocation; the cranial cavity was carefully exposed and the brain dissected to excise tissue specimens from the hippocampus for histological studies. Blood samples were also collected through cardiac puncture and then centrifuged to obtain serum used for the biochemical parameter. The one-way Analysis of Variance was the statistical tool used to evaluate the differences in concentration of the electrolytes, and data was expressed as means ± SD, while P&lt; 0.05 was taken as a significant value. The results showed the extract to have a mitigating effect by alleviating lead-acetate induced histopathological distortions of the hippocampal pyramidal neurons and by counteracting the neurochemical alterations in brain electrolyte ion. The findings of this research therefore indicate that the leaf aqueous extract of <em>O. gratissimum</em> has anti-toxic properties and may therefore be explored by pharmaceuticals in search of alternative treatment for lead poisoning.</p> 2021-04-17T00:00:00+00:00 ##submission.copyrightStatement##