Hepatotoxicological Evaluation of Parsonsia straminea (R.Br) F. Muel Stem Bark Crude Extract in Mice
Ozakieoniso James Kemelayefa
*
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Nigeria.
Bonsome Bokolo
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Science, Niger Delta University, Wilberforce Island, Nigeria.
Amarachi Favour Morka
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Toxicity is defined as the degree to which a substance can harm humans or animals. In reality, every entity that makes substances is undoubtedly labelled poisonous except it is quantified to make safety certain for therapeutic purposes. Herbal medicines are generally considered to be safe and efficacious among people of various ethnic backgrounds globally. The plant Parsonsia straminea has been traditionally claimed to be used in arthritis and seizures, although it is not widely explored. P. straminea a plant used medicinally cannot be said to be free from toxicity owing to fact on its use.
Aim of the Study: The aim of the study is to assess the potential hepatotoxicity of P. straminea stem bark extract in mice
Methodology: For the study, about thirty rodents (mice) were set into six groups with five (5) mice in each group. The study groups (GPs) include 1=0.2 ml/kg of distilled water as control; 2 to 6=50,100, 200, 400 and 800 mg/kg of P. straminea extract. The harvested tissues were sent for histopathological examination.
Results: This study has proven that the extract relatively impacted no significant toxicity on the liver enzymes such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin (ALB) aspartate aminotransferase (AST) and total protein (TP).
Conclusion: The study findings have shown that the ethanolic stem bark of P. straminea possesses relatively no remarkable toxicity impact on the liver as revealed in the liver enzymes and the histology assessment.
Keywords: Toxicity, liver, P. straminea, liver enzymes, histology