Comparative Study of Effectiveness of Haloperidol Versus Olanzapine among Patients with Schizophrenia

Dhanalakshmi R

Department of Pharmacology, Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, 611102, Tamilnadu, India.

Hari Shankar R

Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, 611102, Tamilnadu, India.

Hemachandar C

Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, 611102, Tamilnadu, India.

Janeviennygrace J *

Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, 611102, Tamilnadu, India.

*Author to whom correspondence should be addressed.


Abstract

Aim: To compare the efficacy of oral Typical Antipsychotic drug [Haloperidol] Group A versus oral Atypical Antipsychotic drug [Olanzapine] Group B in patients who met the criteria for schizophrenia. This study includes observe and compare the positive symptoms and negative symptoms in Group A and Group B by using PSYRATS scale and negative symptom assessment tool.

Study Design:  Prospective comparative observational study.

Place and Duration of Study: The study was carried from April 2023 – September 2023 at Psychiatric Outpatient Department in the Government Medical College and Hospital,   Nagapattinam.

Methodology: The study sample comprised 60 patients [N=60], The 30 subjects were in Group A and 30 subjects were in Group B who met the SCID – DSM V criteria and also include criteria 1. Age between 22 – 65 years. 2. Subject should have Minimum mental state examination [MMSE] score between 25 – 30. Paired and Unpaired t test was performed to observe statistical significance.

Results: Out of 60 patients Olanzapine was associated with a mean baseline to endpoint improvement of ( -22.77) versus a Mean change of ( -14.39) in Haloperidol. Olanzapine [Group B] had higher mean difference than Haloperidol [Group A].

Conclusion: By using PSYRATS scale and Negative symptom assessment tool, Olanzapine treated group were numerically better than the Haloperidol treated group in both Negative and Positive Symptoms.

Keywords: Haloperidol, negative symptom assessment tool, olanzapine, PSYRATS scale, Schizophrenia


How to Cite

R, Dhanalakshmi, Hari Shankar R, Hemachandar C, and Janeviennygrace J. 2024. “Comparative Study of Effectiveness of Haloperidol Versus Olanzapine Among Patients With Schizophrenia”. Journal of Advances in Medical and Pharmaceutical Sciences 26 (10):12-19. https://doi.org/10.9734/jamps/2024/v26i10717.