Coagulation Parameters among Individuals with Hepatitis B Infections in Okada, Edo State, Nigeria
Mitsan Olley *
Department of Medical Laboratory Science, Igbinedion University Okada, Nigeria.
Sule Zekeri
Department of Obstetrics and Gynaecology, Igbinedion University Okada, Nigeria.
Aghatise Kevin Erhamwonyi
Department of Medical Laboratory Science, Igbinedion University Okada, Nigeria.
Maureen Uchechukwu Okwu
Department of Microbiology, Igbinedion University Okada, Nigeria.
Aiyanyor David Osayomwanbo
Pathology department, Igbinedion University Teaching Hospital, Okada, Nigeria.
Osaiyuwu Osarenren Clement
Department of Medical Laboratory Science, Igbinedion University Okada, Nigeria.
Izevbuwa Osazee Ekundayo
Department of Microbiology, Igbinedion University Okada, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Hepatitis B Viral (HBV) infection is a condition of inflammation of the liver. The Liver plays a vital role in the body which includes filtration of the blood, production of coagulation proteins and also as a storage organ. In this study, alteration of some coagulation parameters which include, Prothrombin time (PT), activated partial thromboplastin time (APTT), Platelets counts (PLATS) were determined in sixty (60) known seropositive individuals using standard haemostatic techniques. There was a significant reduction in the mean value (mean values) on platelet counts in the seropositive individuals (p- value) compared to the control group (mean value), also revealed in this study is an increase in the mean-time which was significant of PT among test individuals compared to seronegative controls individuals, there was an increase prothrombin time as well as Activated partial prothrombin time with both having p- values < 0.001. The average PT and APTT were 25.53 and 48.89 respectively. Individuals with Hepatitis B infection are thus liable to thrombocytopenia if not managed.
Keywords: Coagulation parameters, hepatitis b, thrombocytopenia, fibronolysis