Effects of Diabetes and Hypertension on Placenta

Fahmida Khatoon *

Biochemistry Department, College of Medicine, University of Ha’il, Saudi Arabia and King Saud Medical City, Central Health Cluster One, Riyadh, KSA.

Reem Falah Alshammari

United Medical College, Pakistan.

Atheer Alturki

Department of Family and Community Medicine, Unaizah College of Medicine and Medical Science, Qasim University, KSA.

Rasha Alarfaj

Department of Family and Community Medicine, Unaizah College of Medicine and Medical Science, Qasim University, KSA.

Rania Abdeen Hussin Abdalla

Department of Obstetrics and Gynecology, College of Medicine, University of Hail, KSA.

Abeer Hassan Elhaj

Family and Community Medicine Department, College of Medicine, University of Ha’il, KSA.

Ebtehaj Saud Almughais

Family and Community Medicine Department, College of Medicine, University of Ha’il, KSA.

Fatima Fahad Alreshidi

Family and Community Medicine Department, College of Medicine, University of Ha’il, KSA.

Rana Aboras

Family and Community Medicine Department, College of Medicine, University of Ha’il, KSA.

Amel Bakri M. Elhag

Pathology Department, College of Medicine, University of Ha’il, KSA.

Zahid Balouch

United Medical College, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

Placental insufficiency is the failure of the placenta to supply nutrients to the fetus and remove toxic wastes; it is a common cause of intra uterine growth restriction (IUGR), fetal distress peri and postnatal mortality. Specifically gestational diabetes and hypertension during pregnancy alters placental architecture which contributes to insufficiency of the placenta. Placenta is the most accurate record of infant’s prenatal experiences. Clinical condition such as hypertension and diabetes that complicate pregnancy leads to significant structural changes in placenta, these histological changes and  morphological alterations in placenta lead to insufficiency, resulting in IUGR and fetal distress. In the present study morphology of placentas collected from diabetic and hypertensive pregnancy will be observed, the histo-pathological findings will be recorded and correlated to birth weight, APGAR scores and congenital anomalies of babies and will be compared to the findings in normal placentas also. This study will be beneficial for obstetrician and pediatrician in gathering knowledge about patho genesis of placental insufficiency; it will add to the knowledge on placental morphology and will high light the abnormalities in placental  anatomy.

Keywords: Placental insufficiency, congenital anomalies, toxic wastes, hypertension


How to Cite

Khatoon, Fahmida, Reem Falah Alshammari, Atheer Alturki, Rasha Alarfaj, Rania Abdeen Hussin Abdalla, Abeer Hassan Elhaj, Ebtehaj Saud Almughais, Fatima Fahad Alreshidi, Rana Aboras, Amel Bakri M. Elhag, and Zahid Balouch. 2022. “Effects of Diabetes and Hypertension on Placenta”. Journal of Advances in Medical and Pharmaceutical Sciences 24 (10):33-36. https://doi.org/10.9734/jamps/2022/v24i10581.

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Author Biography

Fahmida Khatoon, Biochemistry Department, College of Medicine, University of Ha’il, Saudi Arabia and King Saud Medical City, Central Health Cluster One, Riyadh, KSA.

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