Anti-inflammatory Activities of the Leaf Chloroform Extract of Palisota hirsuta
Madubuike G. Kelechi *
Department of Veterinary Physiology, Pharmacology and Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
Asuzu I. Uzoma
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Objective: To investigate the anti-inflammatory activity of the chloroform leaf extract of Palisota hirsuta (CLEPH).
Methods: CLEPH was evaluated for anti-inflammatory activity using standard experimental models of inflammation namely: Croton oil-induced mouse ear edema, carrageenan-induced rat paw edema and cotton pellet granuloma test. The activities of the extract at different doses were compared to indomethacin, a standard anti-inflammatory drug.
Results: In all the experiments, the chloroform extract of P. hirsuta showed in a dose-dependent manner, anti-inflammatory effects which were significant (p˂0.05) and comparable to those of indomethacin.
Conclusion: The results showed that CLEPH possess significant anti-inflammatory activity. This supports its use as an anti-inflammatory recipe in folk medicine.
Keywords: Palisota hirsute, leaf extract, inflammation, croton oil, carrageenan, granuloma