Intralipid in the Target Treatment of Lipid Peroxidation Disorder Caused by Oxidative and Nitro- Galogenic Stress in Patients with SARS-Cov2 / COVID / 19
Maria Vasilieva
World Academy of Medical Sciences, Netherlands and Republic of Moldova. and State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Irina Vasilieva
World Academy of Medical Sciences, Netherlands and Republic of Moldova. and State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Ilie Vasiliev *
World Academy of Medical Sciences, Netherlands and Republic of Moldova.
Stanislav Groppa
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Gh. Ghidirim
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Mircea Bețiu
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Valentina Diug
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova. and Mother and Child Institute, Republic of Moldova.
Nicolae Bacinschi
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Eugen Diug
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Olga Tagadiuc
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Pavel and Tanea Globa
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Ninel Revenco
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova. and Mother and Child Institute, Republic of Moldova.
Gheorghe Plăcintă
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Lorina Vudu
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Jana Bernic
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova. and Mother and Child Institute, Republic of Moldova.
Gheorghe Caradja
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Lilian and Elena Globa
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Serghei Ignatenco
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Ludmila Serbenco
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Andrei Cealan
State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova.
Mirta D'Ambra
World Academy of Medical Sciences, Netherlands and Republic of Moldova.and Department of Medical Sciences, Medicine University of Buenos Aires, Public Health UBA, Minister Health UN Coordinator, Argentina.
Oleg Tarabrin
Department of Anaesthesiology of Reanimatology, Odessa National Medicine University, Ukraine.
*Author to whom correspondence should be addressed.
Abstract
Background: In the current proposal, we used the intralipid in standard therapy against COVID / 19 as an energy carrier for parenteral nutrition in critically ill patients. In patients receiving intralipid, there was an accelerated recovery of the lungs, a decrease in markers of endogenous intoxication (EI), tissue hypoxia and an improvement in general condition. In the absence of Intralipid in the intensive care unit, there was a slow recovery of the lungs and a more prolonged improvement in the general condition with the preservation of EI markers (cytolytic enzymes, C-reactive protein, platelets) and tissue hypoxia (pCO2 AV> 6 mm Hg). Collectively, Intralipid has been seen in the targeted LPO treatment plan for oxidative and nitro-galogenic stress in SARS-Cov2 / COVID / 19 patients.
Keywords: Intralipid, syndrome of maria&Irina vasilieva, SARS-Cov2/COVID/19, reactive oxygen species, reactive nitrogen species, oxidative and nitro-galogenic stress.