Relationship between Different Anthropometric Measurements and Interleukin-1β, Interleukin-17, Interleukin-27 and Interleukin-35 Levels for Iraqi Infertile Women with Polycystic Ovary Syndrome
Sundus Fadhil Hantoosh *
Department of Training and Development, DNA Forensic Center for Research and Training, AL-Nahrain University, Baghdad, Iraq.
Dheaa Shamikh Zageer
DNA Forensic Center for Research and Training, AL-Nahrain University, Baghdad, Iraq.
Farah T. O. Al-Jumaili
Department of Molecular and Medical Biotechnology, College of Biotechnology, AL-Nahrain University, Baghdad, Iraq.
*Author to whom correspondence should be addressed.
Abstract
Aims: The study aimed to study impact of type and amount of body fat distribution on interleukin-1β, interleukin-17, interleukin-27, and interleukin-35 levels and on immunologic infertility.
Study Design: The study was carried on infertile polycystic ovarian syndrome women.
Place and Duration of Study: The study was performed with study subjects attended consultant clinic of Higher Institute for Infertility Diagnosis and Assisted Reproductive Technologies at AL-Nahrain University in Baghdad/Iraq during the period from February 2016 to April 2016.
Materials and Methods: Twenty-six infertile polycystic ovarian syndrome women were enrolled in this study. Body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR) measurements were calculated to all cases. Serum interleukin-1β (IL-1β), interleukin-17 (IL-17), interleukin-27 (IL-27), and interleukin-35 (IL-35) concentrations were measured on cycle day 2.
Results: Significant difference in distribution according to BMI, WC, and WHR (P=0.0001, P=0.0001, P=0.04, respectively). Significant difference in IL-1β concentrations according to WHR (P=0.04). Significant difference in IL-17 concentrations according to BMI, WC, and WHR (P=0.02, P=0.03, P=0.008, respectively). Significant difference in IL-27 concentrations according to WC (P=0.03). Significant difference in IL-35 concentrations according to BMI and WC (P=0.0001, P=0.0001, respectively).
Conclusions: Amount and type of body fat distribution considerably affected and altered IL-1β, IL-17, IL-27, and IL-35 concentrations and consequently had a role in immunologic infertility.
Keywords: PCOS, anthropometric measurements, interleukin-1β, interleukin-17, interleukin-27, interleukin-35, infertility