Journal of Advances in Medical and Pharmaceutical Sciences

Bis(4,6-dimethyl-2-pyridylseleno)zinc 3,3’-dicyanide, A Potent Antifungal Agent

V. H. Shah

Department of Chemistry, Saurashtra University, Rajkot, 360005, India.

A. A. Zohri

Department of Biology, Assiut University, Assiut, 71516, Egypt.

P. K. Talpara

Department of Chemistry, Saurashtra University, Rajkot, 360005, India.

P. A. Sangala

Department of Chemistry, Saurashtra University, Rajkot, 360005, India.

M. A. Abdelazim *

Department of Chemistry, Saurashtra University, Rajkot, 360005, India.

*Author to whom correspondence should be addressed.

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Abstract

A novel zinc chelate of 3-cyano-4,6-dimethyl-2(1H)-selenone pyridine was synthesized and its structure was confirmed on the basis IR, ¹H NMR, ¹³C NMR spectral analyses and TOF mass spectrometry. Biological screening against Candida glabrata reveals a greater antifungal activity of the zinc chelate as compared to the fluconazole reference drug.

Keywords: Synthesis, bis(4,6-dimethyl-2-pyridylseleno)zinc 3,3’-dicyanide, fluconazole, antifungal activity, Candida glabrata

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