Basic Pharmacology of NG -Nitro – L – Arginine Methyl Ester
Muhanad S. Abdelwahab
Department of Physiology, Napata College, Khartoum, Sudan.
Mukhallad A. M. Mohammed
Department of Physiology, Jordan University of Science and Technology, Irbid, Jordan.
H. M. Abdelwhab
Department of Pharmacology, National Ribat University, Khartoum, Sudan.
Mazin S. Abdalla Mohamed *
Department of Physiology, Napata College, Khartoum, Sudan.
Mansour Abdelgader Bellal
University of Science and Technology, Khartoum, Sudan.
*Author to whom correspondence should be addressed.
Abstract
NG – Nitro- L- arginine methyl ester (L-NAME) is a synthetic drug in which a quanidino is substituted for L-arginine analoques. It is a competitive enzyme inhibitor which inhibits nitric oxide synthase, hence, decreasing nitric oxide production [1].
Keywords: L-NAME, pharmacodynamics, pharmacokinetic, NG- L- arginine, Nitric Oxide (NO), hypertension