Evaluation of Plasma Levels of Interleukin 6 and Iron Status of Volleyball Players in a Nigerian University
Journal of Advances in Medical and Pharmaceutical Sciences,
Page 18-23
DOI:
10.9734/jamps/2022/v24i630307
Abstract
To determine the levels of interleukin 6 (IL-6) and iron status of volleyball players in Madonna University, Elele, Rivers State, Nigeria. A total number of 80 subjects were recruited for the study, comprising of 40 subjects before playing volleyball (20 males and 20 females) and 40 subjects after playing volleyball (20 males, 20 females) from Madonna University Nigeria, Elele Campus, Rivers State, Nigeria. The data obtained from the study were presented as Mean ± SD in tables and analysed using student t-test for parametric data using SPSS version 20. The level of significance was set at p<0.05. The results of Table 1 showed that there was increase (p=0.003) in interleukin 6 (IL-6) after playing volleyball compared to before playing volleyball and no significant change (0.079) in iron after playing volleyball compared to before playing volleyball. Table 2 showed that there was no significant increase (p=0.164) in interleukin 6 (IL-6) of males compared to females and no significant change (p=0.589) in iron of males compared to females. Table 3 showed that there was no significant increase (p=0.921) in interleukin 6 (IL-6) of volleyball players aged 15-25 Years compared to volleyball players aged 26-35 Years and no significant change (p=0.503) in iron of volleyball players aged 15-25 Years compared to volleyball players aged 26-35 Years respectively. The study found an increase in interleukin 6 (IL-6) levels in volleyball players after games as opposed to levels before games, demonstrating that physical exercise raises interleukin 6 levels while having no impact on iron levels.
Keywords:
- Interleukin 6
- iron
- volleyball
- inflammation
How to Cite
References
Nakagawa H, Tamura T, Mitsuda Y, Goto Y, Kamiya Y, Kondo T et al. Inverse correlation between serum interleukin-6 and iron levels among Japanese adults: A cross-sectional study. BMC Hematol. 2014;14(1):6.
White GE, West SL, Caterini JE, Di Battista AP, Rhind SG, Wells GD. Massage therapy modulates inflammatory mediators following sprint exercise in healthy male athletes. J Funct Morphol Kinesiol. 2020;5(1):1-11.
Cabral-Santos C, Gerosa-Neto J, Inoue DS, Panissa VL, Gobbo LA, Zagatto AM et al. Similar anti-inflammatory acute responses from moderate-intensity continuous and high-intensity intermittent exercise. J Sports Sci Med. 2015;14(4): 849-56.
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271-6.
D’Angelo G. Role of hepcidin in the pathophysiology and diagnosis of anemia. Blood Res. 2013;48(1):10-5.
Wolf J, Rose-John S, Garbers C. Interleukin-6 and its receptors: a highly regulated and dynamic system. Cytokine. 2014;70(1):11-20.
Obeagu EI, Vincent CCN, Chinedu-Madu JU. Studies on some cytokines of apparently healthy Nigerian women aged 10-40 years. Int J Curr Res Med Sci. 2019;5(12):24-30.
Ifeanyi OE, Uzoma OG, Amaeze AA, Ijego AE, Felix CE, Ngozi AF et al. Maternal expressions (serum levels) of alpha tumour necrosis factor, interleukin 10, interleukin 6 and interleukin 4 in malaria infected pregnant women based on parity in a Tertiary Hospital in Southeast, Nigeria. J Pharm Res Int. 2020;32(23):35-41.
Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today. 1990; 11(12):443-9.
Kang S, Narazaki M, Metwally H, Kishimoto T. Historical overview of the interleukin-6 family cytokine. J Exp Med. 2020;217(5):4.
Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc. 2004;63(2):263-7.
Reihmane D, Dela F. Interleukin-6: possible biological roles during exercise. Eur J Sport Sci. 2014;14(3):242-50.
Estrela AL, Zaparte A, Da Silva JD, Moreira JC, Turner JE, Bauer ME. High volume exercise training in older athletes influences inflammatory and redox responses to acute exercise. J Aging Phys Act. 2017;25(4):559-69.
Zhao L, Wang X, Yang Y. Association between interleukin-6 and the risk of cardiac events measured by coronary computed tomography angiography [international journal]. Int J Cardiovasc Imaging. 2017;33(8):1237-44.
Coates TD. Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radic Biol Med. 2014;72:23-40.
Ganz TN, E. Hepcidin and iron homeostasis. Biochim Biophys Acta Mol Cell Res. 2012;1823:1434-43.
Finch CA, Huebers MD. Perspectives in iron metabolism. N Engl J Med. 1982;25:1520-8.
Dallman PR. Manifestations of iron deficiency. Semin Hematol. 1982;19(1):19-30. PMID 6763336.
Azevedo JL Jr, Willis WT, Turcotte LP, Rovner AS, Dallman PR, Brooks GA. Reciprocal changes of muscle oxidases and liver enzymes with recovery from iron deficiency. Am J Physiol. 1989;256 (3Pt 1):E401-5.
Cullen T, Thomas AW, Webb R, Hughes MG. Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume. Appl Physiol Nutr Metab. 2016;41(8):803-8.
Obeagu EI, Amedu GO, Okoroiwu IL, Okafor CJ, Okun O, Ochiabuto OMTB et al. Evaluation of plasma levels of interleukin 6 and iron status of football players in a Nigerian university. J Pharm Res Int. 2021;33(59B):383-8.
Ronsen O, Lea T, Bahr R, Pedersen BK. Enhanced plasma IL-6 and IL-1RA responses to repeated vs. single bouts of prolonged cycling in elite athletes. J Appl Physiol (1985). 2002;92(6): 2547-53.
Hoffman-Goetz L, Pedersen BK. Exercise and the immune system: a model of the stress response? Immunol Today. 1994;15(8):382-7.
Pedersen BK, Bruunsgaard H, Klokker M, Kappel M, MacLean DA, Nielsen HB et al. Exercise induced immunomodulation-possible roles of neuroendocrine and metabolic factors. Int J Sports Med. 1997;18;Suppl 1:S2-7.
Ruiz-Argüelles GJ. Laboratory measurement of human cytokines. J Int Fed Clin Chem. 1995;7(1):12-5.
Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen JN, Pedersen BK. A trauma-like elevation in plasma cytokines in humans in response to treadmill running. J Physiol. 1998;508:949-53.
Rivier A, Pène J, Chanez P, Anselme F, Caillaud C, Préfaut C et al. Release of cytokines by blood monocytes during strenuous exercise. Int J Sports Med. 1994;15(4):192-8.
Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. The cytokine balance and strenuous exercise: TNF-alpha, IL-2beta, IL-6, IL-1RA, sTNF-r1, sTNF-r2, and IL-10. J Physiol. 1999;515(1):287-91.
Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK. Evidence that IL-6 is produced in skeletal muscle during intense long-term muscle activity. J Physiol. 1998;508(3):949-53.
Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen JN, Pedersen BK. A trauma-like elevation in plasma cytokines in humans in response to treadmill running. J Physiol (Lond). 1998;508:949-53.
Pedersen BK, Steensberg A, Schjerling P. Exercise and interlmeukine-6. Curr Opin Hematol. 2001;8(3):137-41.
Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol. 1998;76(5):505-11.
Obeagu EI, Obeagu GU, Emeonye OP, Jakheng spe. An upadte on interleukin 6 and iron status of volleyball players. Madonna University Journal of Medicine and Health Sciences.2022;, 2(2), 41-74.
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