C-reactive Protein, Trace Element and Lipid Profile in Cardiovascular Disease
Olooto E. Wasiu *
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu Campus, Nigeria
Amballi A. Adetola
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu Campus, Nigeria
A. Aiyedun
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu Campus, Nigeria
Onayemi A. Adedeji
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu Campus, Nigeria
Olawale O. Oladipupo
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu Campus, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Background: The increase in consumption of industrial processed food, economic instability consequent to global economic recession; job losses; increase incidence of diabetes and chronic kidney disease; increase steroids use; dyslipidemia; and obesity has been implicated in the global increase in hypertension and corresponding heart diseases. This study evaluates the pattern of C-reactive protein, trace element and lipid profile in cardiovascular disease between January 2016 and August 2017.
Method: The study was a cross-sectional. A total of one hundred participants (consisting of 50 patients and 50 control subjects mean age 56.12±11.4 and 59.8±10.8 yrs respectively) attending medical outpatient clinic of Ogun state general hospital Abeokuta on account of hypertensive heart diseases and other cardiovascular related illness were recruited for the study. Relations that accompanied the patients to the clinic and some workers of the hospital were recruited as controls. A structured questionnaire was administered to obtain some demographic data from all the participants. Blood pressure was measured using mercurial sphygmomanometer. Venous blood was collected from all the participants, allowed to clot and centrifuged at 3000 rpm for 5 min to obtain the serum. Serum C-reactive protein, total cholesterol, triglycerides, HDL-C, Zinc, Magnesium and Selenium were measured.
Results: Result showed no significant differences in age and height (p > 0.05); a statistically significant increase in weight, BMI, SBP, DBP, serum total cholesterol, LDLC, VLDLC, triglyceride, AI, CRI and CRP (p < 0.05); and a statistically significant decrease in serum HDLC, trace element (Zn, Mg, and Se) (p < 0.05) among the hypertensive patients when compared with the control subjects.
Conclusion: Base on the result obtained from this study, CVD is associated with abnormalities in inflammatory markers, lipid profile, and antioxidant micronutrients.
Keywords: Cardiovascular disease, hypertension, lipid profile, micronutrient, antioxidants