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This study evaluated the dose-dependent effect of avocado (Persea americana) peel hydroethanolic extract on antioxidant status of heart and kidney tissue homogenates in wistar rats. A total of 60 wistar rats were used and the study period lasted for 42 days. The animals were randomly sampled into six (6) groups; Group i -normal untreated wistar rats, ii -P. americana peel extract (50 mg/kg), iii-lead acetate (100 mg/kg), iv- P. americana peel extract (50 mg/kg) + lead acetate (100 mg/kg), v-P. americana peel extract (100 mg/kg) + lead acetate (100 mg/kg) and vi- P. americana peel extract (150 mg/kg) + lead acetate (100 mg/kg). Biomarkers assayed for include antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase; non-enzyme antioxidant reduced glutathione; isoprostanes and malondialdehyde. The extract caused a dose-dependent increase in antioxidant enzymes and non-enzyme markers when administered alone and when combined with lead acetate most especially at doses 100 mg/kg and 150 mg/kg. The extract also caused a significant dose-dependent decrease in isoprostanes and malondialdehyde. From the outcome of this study, avocado peel extract has an effect on antioxidant status of both the heart and kidney, but this effect is dose-dependent.