Assessment of the Effects of Moringa oleifera Oil, Anacardium occidentale Oil and Vitamin C and E on the Reticular Fibres of Cadmium- Induced Liver Damage in Wistar Rats
O. D. Omotoso
Department of Anatomy, Kogi State University, Anyigba, Kogi State, Nigeria
S. A. Adelakun *
Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
U. A. Yusuf
Department of Human Anatomy, Kampala International University dar es salaam Campus, Tanzania
O. O. Adeleye
Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
O. O. Adeyinka
Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Background: Cadmium is one of the most toxic pollutants in the environment. This study aims at assessment of the effects of Moringa oleifera oil, Anacardium occidentale oil and vitamin C and E on the reticular fibres of cadmium- induced liver damage in wistar rats.
Methods: Thirty-five (35) wistar rats (80-180 g) were randomly selected and divided into seven groups of five rats each after acclimatization for two week. Group A served as control group received phosphate buffer, Group B received Cadmium only (3.5 mg/kg body weight). Group C received Vitamin C and Vitamin E, Group D received Vitamin C and Vitamin E and Cadmium. Group E received Cadmium and Moringa oleifera oil, Group F received Cadmium and Cashew nut oil and Group G received Cadmium (3.5 mg/kg body weight) and Moringa oleifera oil and Anacardium occidentale nut oil.
Results: Microscopic examination revealed normal histo- architecture of the liver, the portal vein and the reticular fibres were seen clearly and there was orderly arrangement of the reticular fibres in group A and in treatment groups B, C, D, E, F and G there was enlargement of the portal vein, distortion of reticular fibres and sinusoidal and restoration of the reticular fibres.
Conclusion: This therefore suggests that Moringa oleifera oil and Anacardium occidentale nut oil have ameliorative effects that led to the regeneration of the damaged and distorted reticular fibres.
Keywords: Moringa oleifera, Anacardium occidentale, oxidative stress, liver, cadmium