Journal of Advances in Medical and Pharmaceutical Sciences

This study evaluated the effects of different concentrations of quail egg solution on glycemia and some antioxidant markers in alloxan-induced diabetic rats. Thirty adult male albino rats were assigned to 5 groups of 6 rats per group. Groups 2, 3, 4 and 5 were made diabetic by single intraperitoneal injection of 160 mg/kg alloxan monohydrate. Upon establishment of diabetes (fasting blood glucose levels above 126 mg/dl), the rats in groups 2, 3 and 4 were respectively administered with 30, 15 and 7.5 mg/ml orally daily for 21 days. Groups 1 and 5 were administered with distillled water. Fasting blood glucose (FBG) levels of the rats were assessed 1 h, 6 h, 24 h and 21 days post treatment. On the 21^st day, blood samples were collected for malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (RSH) assays. Results indicate that administration of quail egg solution at the concentration of 30 mg/ml to the diabetic rats significantly (p< 0.05) reduced the FBG from 343.80 to 87.20 mg/dl on day 21 post treatment. There was significant (p< 0.05) reduction in the mean MDA values of the 30 mg/ml-treated groups compared to the negative control group. The SOD activity and glutathione levels of 30 mg/ml-treated diabetic rats were significantly (p< 0.05) higher compared to that of the diabetic untreated group. It was concluded that administration of quail egg solution especially at the concentration of 30 mg/ml to the diabetic rats resulted in hypoglycemia and improvement in the levels and activities of in vivo antioxidant parameters.