Main Article Content
Objective: To determine the relationship between illness perception, medication adherence and health related quality of life in patients living with epilepsy.
Design: A cross-sectional prospective survey among patients living with epilepsy recruited from two tertiary referral centers in Nigeria.
Methods: Patients’ illness perception, adherence to antiepileptic drugs, and health related quality of life were determined using the brief illness perception questionnaire (BIPQ), the eight-item Morisky medication adherence scale (MMAS-8), and the patient weighted quality of life in epilepsy instrument (QOLIE-10-P) respectively. Correlation and linear regression analysis were used to test the relationship between the assessment variables. Statistical significance was set at p < 0.05.
Results: Multivariate linear regression revealed that patients’ medication adherence score was predicted by their illness perception score (B = -0.030; p = 0.033). Also, patients’ QOLIE score was predicted by their illness perception score (B = -0.318; p = 0.0001).
Conclusion: In patients living with epilepsy, illness perception is a predictor of their adherence to antiepileptic drug regimen and their health-related quality of life.
International League against Epilepsy. Epilepsy – Out of the shadows: European declaration on epilepsy. Epilepsia. 2003;44(Suppl. 6):2-3.
International League against Epilepsy. Quality of life: General considerations. Epilepsia. 2003;44(Suppl. 6):57-58.
Aldenkamp AP, De Krom M, Reijs R. Newer antiepileptic drugs and cognitive issues. Epilepsia. 2003;44(Suppl. 4):21-29.
Drazkowski J. An overview of epilepsy and driving. Epilepsia. 2007;48(Suppl 9):10-2.
Westphal-Guitti AC, Alonso NB, Migliorini RC, Da Silva TI, Azevedo AM, Caboclo LO, Sakamoto AC, Yacubian EM. Quality of life and burden in caregivers of patients with epilepsy. J NeurosciNurs. 2007;39 (6):354-60.
Elwes RD, Marshall J, Beattie A, Newman PK. Epilepsy and employment. A community based survey in an area of high unemployment. Journal of Neurology, Neurosurgery and Psychiatry. 1991;54:200-203.
Sabat´e E. Adherence to long-term therapies: Evidence for action. World Health Organization, Geneva, Switzerland; 2003.
Solomon MD, Majumdar SR. Primary non-adherence of medications: lifting the veil on prescription-filling behaviors. Journal of General Internal Medicine. 2010;25(4): 280–281.
Broadbent E, Petrie KJ, Main J, Weinman J. The brief illness perception questionnaire. J Psychosom Res. 2006;60:631–7.
Cramer JA. Assessing the severity of seizures and epilepsy: Which scales are valid? Current Opinion Neurology. 2001; 14:225-229.
Morisky DE, Green LW, Levine D. Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care. 1986;24(1):67-74.
Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. Journal of Clinical Hypertension. 2008;10(5):348–354.
Tan X, Patel I, Chang J. Review of the four item Morisky medication adherence scale (MMAS-4) and eight item Morisky Medication Adherence Scale (MMAS-8). Innovations in Pharmacy. 2014;5(3):165.
Lam WY, Fresco P. Medication adherence measures: An overview. BioMed Research International; 2015;12.
Article ID 217047. Hindawi Publishing Corporation.
Cramer JA. Assessing the severity of seizures and epilepsy: Which scales are valid? Current Opinion Neurology. 2001;14:225-229.
Bewick V, Cheek L, Ball J. Statistics review 7: Correlation and regression. Crit Care. 2003;7(6): 451–459.
Petrie KJ, Weinman J. Why illness perceptions matter. Clin Med. 2006;6:536-9.
Donkin L, Ellis CJ, Powell R, Broadbent E, Gamble G, Petrie KJ. Illness perceptions predict reassurance following negative exercise testing result. Psychol Health. 2006;21:421–30.
Frostholm L, Fink P, Christensen KS, Toft T, Oernboel E, Olesen F, Weinman J. The patients’ illness perceptions and the use of primary health care. Psychosom Med. 2005;67:997.
Boylan LS, Flint LA, Labovitz DL, Jackson SC., Starner K, Devinsky O. Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology. 2004;62(2).
Scharloo M, Kaptein AA, Weinman J, Bergman W, Vermeer BJ, Roojimans HG. Patients’ illness perceptions and coping as predictors of functional status in psoriasis: A 1-year follow-up. Br J Dermatol. 2000;142:899–907.
Petrie KJ, Cameron L, Ellis CJ, Buick D, Weinman J. Changing illness perceptions after myocardial infarction: an early intervention randomized controlled trial. Psychosom Med. 2002; 64:580– 6.
Eshiet U, Okonta J, Ukwe C. The efficacy of a pharmacist implemented educational treatment programme for people with epilepsy: A report of a randomised controlled trial. Seizure: European Journal of Epilepsy. 2019;69: 147–15.