Hepatoprotective and Antioxidant Activity of Amorphophallus campanulatus Tubers Extract against Paracetamol - Induced Liver Damage in Rats

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Surendra Kumar Singh
Nripendra Singh
Ritu Singh

Abstract

The present study was to evaluate the hepatoprotective and antioxidant activity of the methanolic and aqueous extracts of Amorphophallus campanulatus (A. campanulatus) tubers against Paracetamol induced liver damage in rats. The administration of extracts at a dose 300 mg/ kg restored the elevated serum enzyme levels to normal. Silymarin was used as a standard reference, exhibited significant hepatoprotective activity. The biochemical and histopathological results proved that Amorphophallus campanulatus tubers had hepatoprotective potency to liver damage due to paracetamol. The increase in the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) shows that the plant may possess antioxidant property. It was concluded from the results that methanolic extract possessed more potent hepatoprotective and antioxidant activity than aqueous extract.

 

Keywords:
Amorphophallus campanulatus tuber, hepatoprotective, paracetamol, silymarin

Article Details

How to Cite
Kumar Singh, S., Singh, N., & Singh, R. (2016). Hepatoprotective and Antioxidant Activity of Amorphophallus campanulatus Tubers Extract against Paracetamol - Induced Liver Damage in Rats. Journal of Advances in Medical and Pharmaceutical Sciences, 11(1), 1-6. https://doi.org/10.9734/JAMPS/2016/29419
Section
Original Research Article